Management
Print
Curriculum Vitae Anna Boguszewska-Chachulska, PhD    

EMPLOYMENT:

  • 2013 CEO, Genomed SA (joint-stock company)
  • 2009-2013 COO, Member of the board of Directors, Genomed Ltd, since 2011 - Genomed SA (joint-stock company)
  • 2007-2009 Genomed Ltd. Co. - co-founder and member of the Advisory Board
  • 2009-2010 Professor at the Institute of Biotechnology, Department of Chemistry, Warsaw University of Technology
  • 2008-Associate Professor at the Institute of Biochemistry and Biophysics
  • 1998-2008 Assistant Professor at the Institute of Biochemistry and Biophysics
  • 1993-1998 Senior research assistant, Institute of Biochemistry and Biophysics
  • 1990-1993 Research assistant

EDUCATION:

  • Studies: Biology Faculty, University of Warsaw, 1984-1990
  • Specialisation: Molecular Biology
  • M.Sc.: Department of Genetics, University of Warsaw, 1990
  • B.Sc.(Equivalent): Biology Faculty, University of Warsaw, 1990
  • Ph.D. in Biochemistry: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, January 1998 
  • Habilitation in Biology Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, October 2008

RESEARCH TRAINING AND EXPERIENCE:

  • August 1998 – June 2000 – post-doctoral training in the laboratory of Dr. Linda E. Hyman at Tulane University in New Orleans in U.S. – looking for the roles of Elongin C in yeast
  • 1996-1998 - leading a project on plant transformation towards potato virus Y resistance financed by a grant of Polish Committee of Scientific Research
  • Laboratoire de Biologie Cellulaire, INRA, Versailles, France - CNRS stipend, October-December 1992, December 1993; October 1995, 1996, 1997
  • EEC grant - April-June 1993, French Government stipend - July-August 1995

TEACHING EXPERIENCE:

  • 2009-2010 Tutor of two M.Sc. and three B.Sc. students

AWARDS:

  • June 30 1998 Polish Scientific Award of Plant Genetics - First prize for “Creative contribution to the plant molecular virology”
  • November 18 1999 Award of Polish Academy of Sciences for co-authoring of a series of works dedicated to “RNA genomes of crop pathogens – structures, functions, control and spread”
  • March 23 2006 Award of IBB PAS for the review published in Prog. Nucleic Acid Res. Mol. Biol. 80, 135-68. “Virus-Like Particles: Models for Assembly Studies and Foreign Epitope Carriers.”
  • December 04 2006 Habilitation stipend for Women in Science 2006 awarded by l’Oréal Polska with a support from Polish UNESCO Commitee

LIST OF PUBLICATIONS:

  • Stankiewicz-Drogoń A, Dörner B, Erker T, Boguszewska-Chachulska AM. Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication. 2010 J Med Chem. 53, 3117-26.
  • Najda-Bernatowicz A, Krawczyk M, Stankiewicz-Drogoń A, Bretner M, Boguszewska-Chachulska AM. Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication. 2010 Bioorg Med Chem. 18, 5129-36.
  • Krawczyk M., Stankiewicz-Drogoń A., Haenni A.-L., and Boguszewska-Chachulska A. Fluorometric assay of helicase activity w: Helicases. Methods and Protocols, Series: Methods in Molecular Biology, Vol.587 Abdelhaleem, Mohamed M. (Ed.) 2010, XII,ISBN: 978-1-60327-354-1
  • Krawczyk M., Wasowska-Lukawska M., Oszczapowicz I., Boguszewska-Chachulska A.M., Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds. 2009. Biol. Chem. 390, 351-360
  • Stankiewicz-Drogon A., Palchykovska L.G., Kostina V.G., Alexeeva, I.V., Shved A.V., and Boguszewska-Chachulska A.M. New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection. 2008. Bioorg. Med. Chem. 16, 8846-8852
  • Gozdek A., Poznański, J., Stankiewicz-Drogoń A. and Boguszewska-Chachulska A.M Circular dichroism analysis for multidomain proteins: studies of the irreversible unfolding of Hepatitis C virus helicase.” 2008. Acta Biochim. Pol. 55, 57-66
  • Gozdek A., Zhukov I., Polkowska A., Poznanski J., Stankiewicz-Drogon A., Pawlowicz J.M., Zagórski-Ostoja W., Borowski P., and Boguszewska-Chachulska A.M. NS3 peptide, a novel potent Hepatitis C virus NS3 helicase inhibitor, its mechanism of action and antiviral activity in the replicon system. 2008. Antimicrob. Agents Chemother. 52, 393-401
  • Boguszewska-Chachulska AM, Krawczyk M, Najda A, Kopanska K, Stankiewicz-Drogon A, Zagorski-Ostoja W, Bretner M. Searching for a new anti-HCV therapy: Synthesis and properties of tropolone derivatives. 2006. Biochem Biophys Res Commun. 341, 641-647
  • Palucha A., Loniewska A., Satheshkumar S., Boguszewska-Chachulska A.M., Umashankar M., Milner M., Haenni A.-L. and Savithri H.S. Virus-Like Particles: Models for Assembly Studies and Foreign Epitope Carriers. 2005. Progress Nucl. Acid Res. Mol. Biol. 80, 135-168
  • Boguszewska-Chachulska A.M and Haenni A.-L. RNA viruses redirect host factors to better amplify their genome. 2005. Adv. Virus Res. 65, 29-61
  • Boguszewska-Chachulska A.M., Krawczyk M., Stankiewicz A., Gozdek A., Haenni A.-L., Strokovskaya L. Direct fluorometric measurement of hepatitis C virus helicase activity. 2004, FEBS Lett. 567, 253-258
  • Hyman L.E., Kwon E., Ghosh S., McGee J., Chachulska A.M., Jackson T., Baricos W.H. Binding to elongin C inhibits degradation of interacting proteins in yeast. 2002. J. Biol. Chem. 277, 15586-15591
  • Zagórski W., Chachulska A., Lipska-Dwużnik A., Flis B., Pałucha A. Molecular phylogeny as a tool for controlling Potato Virus Y spread. Use of agriculturally important genes in biotechnology. G. Hradzina (Ed.) IOS Press, 2000, 148-152
  • Flis B., Chachulska A., Pałucha A. Performance of virus resistant transgenic potatoes. Use of agriculturally important genes in biotechnology. G. Hradzina (Ed.) IOS Press, 2000, 142-147 Doroszewska T., Chachulska A.M. Możliwości uzyskania odporności na choroby wirusowe tytoniu. 2000, Biotechnologia 4 (51), 128-141
  • Jackson T., Kwon E., Chachulska A.M., Hyman L.E. “Novel roles of Elongin C in yeast.” 2000. Bioch. Biophys. Acta 1491, 161-176
  • Chachulska A.M., Chrzanowska M., Robaglia C. and Zagórski W. “Tobacco veinal necrosis determinants are unlikely to be located within the 5’ and 3’ terminal sequences of the potato virus Y genome.” 1997, Arch. Virol., str. 67, 189-197
  • Chachulska A.M., Fakhfakh H., Robaglia C., Granier F., Zagórski W. and Vilaine F. Synthesis of potyvirus full-length cDNA copies suitable for the analysis of genome polymorphism. 1997, J. Virol. Methods 67, 189-197
  • Chachulska A.M., Chrzanowska M., Flis B., Krzymowska M., Lipska-Dwużnik A., Robaglia C. and Zagórski W. Potato and tobacco cultivars transformation towards potato virus Y resistance. 1997, Biotechnologia 4 (39), str. 38-48.
  • Chrzanowska M., Doroszewska T., Chachulska A. Charakterystyka szczepów wirusa Y występujących w Polsce w uprawach tytoniu i ziemniaka. 1997, Progress in Plant Protection/ Postępy w Ochronie Roślin 37 (2), str. 327-329
  • Marie-Jeanne V., Chachulska A.M., Fakhfakh H., Le Romancer M., Robaglia C. et Astier-Manifacier S. "Polymorphisme de sequence dans la region 5' non-codante et P1 de l'ARN de PVY." 1995 , Annales du Tabac, 27(2), str. 59-64
  • Chachulska A.M. i Zagórski W. “Analiza sekwencyjna genomów izolatów wirusa Y ziemniaka” w “ Wybranych zagadnieniach biotechnologii roślin” pod redakcją K. Wypijewskiego. 1996. str. 71-83
  • Marie-Jeanne Tordo V., Chachulska A.M., Fakhfakh H., Le Romancer M., Robaglia C. and Astier-Manifacier S. "Sequence polymorphism in the 5'NTR and in the P1 coding region of Potato Virus Y genomic RNA.", 1995, J.Gen.Virol., 76, str. 939-949
  • Chachulska A.M."Rybozymy - katalityczne czasteczki RNA", 1992, Postepy Biochemii, 38, str.64-74

PATENTS OBTAINED:

  • P-186760 (1997) New binary vector and method of its construction P-186761 (1997) Method of construction of plants resistant to potato virus Y (PVY)

PATENT APPLICATIONS FILLED:

  • P 369883 „Tropolone analogs as inhibitors of NTPase/helicase of viruses belonging to the Flaviviridae family and as antiviral agents”, filed on 09.03.2004
  • P 381377 "New acridone derivatives, method of preparation and their application " filed on 12.21.2006
  • P 381714 „New medical applications of anthracycline antibiotics’ derivatives” filed on 02.07.2007 in the Polish Patent Office, and on 02.07.2008 in the European Patent Office, application No PCT/PL2008/000010