2009-2013 COO, Member of the board of Directors, Genomed Ltd, since 2011 - Genomed SA (joint-stock company)
2007-2009 Genomed Ltd. Co. - co-founder and member of the Advisory Board
2009-2010 Professor at the Institute of Biotechnology, Department of Chemistry, Warsaw University of Technology
2008-Associate Professor at the Institute of Biochemistry and Biophysics
1998-2008 Assistant Professor at the Institute of Biochemistry and Biophysics
1993-1998 Senior research assistant, Institute of Biochemistry and Biophysics
1990-1993 Research assistant
EDUCATION:
Habilitation in Biology Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, October 2008
Ph.D. in Biochemistry: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, January 1998
Studies: Biology Faculty, University of Warsaw, 1984-1990
Specialisation: Molecular Biology
M.Sc.: Department of Genetics, University of Warsaw, 1990
B.Sc.(Equivalent): Biology Faculty, University of Warsaw, 1990
RESEARCH TRAINING AND EXPERIENCE:
August 1998 – June 2000 – post-doctoral training in the laboratory of Dr. Linda E. Hyman at Tulane University in New Orleans in U.S. – looking for the roles of Elongin C in yeast
1996-1998 - leading a project on plant transformation towards potato virus Y resistance financed by a grant of Polish Committee of Scientific Research
Laboratoire de Biologie Cellulaire, INRA, Versailles, France - CNRS stipend, October-December 1992, December 1993; October 1995, 1996, 1997
EEC grant - April-June 1993, French Government stipend - July-August 1995
TEACHING EXPERIENCE:
2019-2024 Co-tutor of two PhD theses
2009-2010 Tutor of two M.Sc. and three B.Sc. students
2004-2009 Tutor of two PhD theses and co-tutor of one PhD thesis
AWARDS:
December 2017 the 2nd place in the first "10" of the most enterprising women in the category of companies below PLN 50 million turnover per year.
May 2011 Genomed S.A. received the Master of Business award in the category of Innovation
December 04 2006 Habilitation stipend for Women in Science 2006 awarded by l’Oréal Polska with a support from Polish UNESCO Commitee
March 23 2006 Award of IBB PAS for the review published in Prog. Nucleic Acid Res. Mol. Biol. 80, 135-68. “Virus-Like Particles: Models for Assembly Studies and Foreign Epitope Carriers.”
November 18 1999 Award of Polish Academy of Sciences for co-authoring of a series of works dedicated to “RNA genomes of crop pathogens – structures, functions, control and spread”
June 30 1998 Polish Scientific Award of Plant Genetics - First prize for "Creative contribution to the plant molecular virology"
LIST OF PUBLICATIONS:
Matczyńska E, Beć-Gajowniczek M, Sivitskaya L, Gregorczyk E, Łyszkiewicz P, Szymańczak R, Jędrzejowska M, Wylęgała E, Krawczyński MR, Teper S and Boguszewska-Chachulska A. Optimised, Broad NGS Panel for Inherited Eye Diseases to Diagnose 1000 Patients in Poland. Biomedicines. 2024, 12:1355. doi: 10.3390/biomedicines12061355.
Sendecki A, Ledwoń D, Nycz J, Wąsowska A, Boguszewska-Chachulska A, Mitas AW, Wylęgała E, Teper S. A deep learning approach to explore the association of age-related macular degeneration polygenic risk score with retinal optical coherence tomography: A preliminary study.
Acta Ophthalmol. 2024 May 18. doi: 10.1111/aos.16710.
Sendecki A, Ledwoń D, Tuszy A, Nycz J, Wąsowska A, Boguszewska-Chachulska A, Wylęgała A, Mitas AW, Wylęgała E and Teper S. Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network. Diagnostics 2024, 14, 770. https://doi.org/10.3390/diagnostics14070770.
Wąsowska A, Sendecki A, Boguszewska-Chachulska A, Teper S.Polygenic Risk Score and Rare Variant Burden Identified by Targeted Sequencing in a Group of Patients with Pigment Epithelial Detachment in Age-Related Macular Degeneration. Genes 2023;14:1707. doi.org/10.3390/genes14091707
Krytkowska E, Ulańczyk Z, Grabowicz A, Safranow K, Kawa MP, Pałucha A, Wąsowska A, Matczyńska E, Boguszewska-Chachulska A, Machalińska A. Influence of Clinical and Genetic Factors on the Progression of Age-Related Macular Degeneration: A 3-Year Follow-Up. J Clin Med. 2023;12(5):1963. doi: 10.3390/jcm12051963
Wąsowska A, Teper S, Matczyńska E, Łyszkiewicz P, Sendecki A, Machalińska A, Wylęgała E, Boguszewska-Chachulska A. Polygenic Risk Score Impact on Susceptibility to Age-Related Macular Degeneration in Polish Patients. J Clin Med. 2022;12(1):295. doi: 10.3390/jcm12010295
Musialik J, Boguszewska-Chachulska A, Pojda-Wilczek D, Gorzkowska A, Szymańczak R, Kania M, Kujawa-Szewieczek A, Wojcieszyn M, Hartleb M, Więcek A. A Rare Mutation in The APOB Gene Associated with Neurological Manifestations in Familial Hypobetalipoproteinemia. Int J Mol Sci. 2020;21(4):1439. doi: 10.3390/ijms21041439
Oliver KL, Franceschetti S, Milligan CJ, Muona M, Mandelstam SA, Canafoglia L, Boguszewska-Chachulska AM, Korczyn A, Bisulli F, Di Bonaventura C, Ragona F, Michelucci, Ben-Zeev B, Straussberg R, Panzica F, Massano J, Friedman D, Crespel A, Engelsen BA, Andermann F, Andermann E, Spodar, Lasek-Bal A, Riguzzi P, Pasini E, Tinuper P, Licchetta L, Gardella E, Lindenau M, Wulf A, Møller RS, Benninger F, Afawi Z, Rubboli G, Reid CA, Maljevic S, Lerche H, Lehesjoki AE, Petrou S, Berkovic SF. Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K+ channel properties. Ann Neurol. 2017;81(5):677-689
Stankiewicz-Drogoń A, Dörner B, Erker T, Boguszewska-Chachulska AM. Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication. 2010 J Med Chem. 53, 3117-26
Najda-Bernatowicz A, Krawczyk M, Stankiewicz-Drogoń A, Bretner M, Boguszewska-Chachulska AM. Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication. 2010 Bioorg Med Chem. 18, 5129-36
Krawczyk M., Stankiewicz-Drogoń A., Haenni A.-L., and Boguszewska-Chachulska A. Fluorometric assay of helicase activity w: Helicases. Methods and Protocols, Series: Methods in Molecular Biology, Vol.587 Abdelhaleem, Mohamed M. (Ed.) 2010, XII,ISBN: 978-1-60327-354-1
Krawczyk M., Wasowska-Lukawska M., Oszczapowicz I., Boguszewska-Chachulska A.M., Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds. 2009. Biol. Chem. 390, 351-360
Stankiewicz-Drogon A., Palchykovska L.G., Kostina V.G., Alexeeva, I.V., Shved A.V., and Boguszewska-Chachulska A.M. New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection. 2008. Bioorg. Med. Chem. 16, 8846-8852
Gozdek A., Poznański, J., Stankiewicz-Drogoń A. and Boguszewska-Chachulska A.M Circular dichroism analysis for multidomain proteins: studies of the irreversible unfolding of Hepatitis C virus helicase.” 2008. Acta Biochim. Pol. 55, 57-66
Gozdek A., Zhukov I., Polkowska A., Poznanski J., Stankiewicz-Drogon A., Pawlowicz J.M., Zagórski-Ostoja W., Borowski P., and Boguszewska-Chachulska A.M. NS3 peptide, a novel potent Hepatitis C virus NS3 helicase inhibitor, its mechanism of action and antiviral activity in the replicon system. 2008. Antimicrob. Agents Chemother. 52, 393-401
Boguszewska-Chachulska AM, Krawczyk M, Najda A, Kopanska K, Stankiewicz-Drogon A, Zagorski-Ostoja W, Bretner M. Searching for a new anti-HCV therapy: Synthesis and properties of tropolone derivatives. 2006. Biochem Biophys Res Commun. 341, 641-647
Palucha A., Loniewska A., Satheshkumar S., Boguszewska-Chachulska A.M., Umashankar M., Milner M., Haenni A.-L. and Savithri H.S. Virus-Like Particles: Models for Assembly Studies and Foreign Epitope Carriers. 2005. Progress Nucl. Acid Res. Mol. Biol. 80, 135-168
Boguszewska-Chachulska A.M and Haenni A.-L. RNA viruses redirect host factors to better amplify their genome. 2005. Adv. Virus Res. 65, 29-61
Boguszewska-Chachulska A.M., Krawczyk M., Stankiewicz A., Gozdek A., Haenni A.-L., Strokovskaya L. Direct fluorometric measurement of hepatitis C virus helicase activity. 2004, FEBS Lett. 567, 253-258
Hyman L.E., Kwon E., Ghosh S., McGee J., Chachulska A.M., Jackson T., Baricos W.H. Binding to elongin C inhibits degradation of interacting proteins in yeast. 2002. J. Biol. Chem. 277, 15586-15591
Zagórski W., Chachulska A., Lipska-Dwużnik A., Flis B., Pałucha A. Molecular phylogeny as a tool for controlling Potato Virus Y spread. Use of agriculturally important genes in biotechnology. G. Hradzina (Ed.) IOS Press, 2000, 148-152
Flis B., Chachulska A., Pałucha A. Performance of virus resistant transgenic potatoes. Use of agriculturally important genes in biotechnology. G. Hradzina (Ed.) IOS Press, 2000, 142-147 Doroszewska T., Chachulska A.M. Możliwości uzyskania odporności na choroby wirusowe tytoniu. 2000, Biotechnologia 4 (51), 128-141
Jackson T., Kwon E., Chachulska A.M., Hyman L.E. “Novel roles of Elongin C in yeast.” 2000. Bioch. Biophys. Acta 1491, 161-176
Chachulska A.M., Chrzanowska M., Robaglia C. and Zagórski W. “Tobacco veinal necrosis determinants are unlikely to be located within the 5’ and 3’ terminal sequences of the potato virus Y genome.” 1997, Arch. Virol., str. 67, 189-197
Chachulska A.M., Fakhfakh H., Robaglia C., Granier F., Zagórski W. and Vilaine F. Synthesis of potyvirus full-length cDNA copies suitable for the analysis of genome polymorphism. 1997, J. Virol. Methods 67, 189-197
Chachulska A.M., Chrzanowska M., Flis B., Krzymowska M., Lipska-Dwużnik A., Robaglia C. and Zagórski W. Potato and tobacco cultivars transformation towards potato virus Y resistance. 1997, Biotechnologia 4 (39), str. 38-48.
Chrzanowska M., Doroszewska T., Chachulska A. Charakterystyka szczepów wirusa Y występujących w Polsce w uprawach tytoniu i ziemniaka. 1997, Progress in Plant Protection/ Postępy w Ochronie Roślin 37 (2), str. 327-329
Marie-Jeanne V., Chachulska A.M., Fakhfakh H., Le Romancer M., Robaglia C. et Astier-Manifacier S. "Polymorphisme de sequence dans la region 5' non-codante et P1 de l'ARN de PVY." 1995 , Annales du Tabac, 27(2), str. 59-64
Chachulska A.M. i Zagórski W. “Analiza sekwencyjna genomów izolatów wirusa Y ziemniaka” w “ Wybranych zagadnieniach biotechnologii roślin” pod redakcją K. Wypijewskiego. 1996. str. 71-83
Marie-Jeanne Tordo V., Chachulska A.M., Fakhfakh H., Le Romancer M., Robaglia C. and Astier-Manifacier S. "Sequence polymorphism in the 5'NTR and in the P1 coding region of Potato Virus Y genomic RNA.", 1995, J.Gen.Virol., 76, str. 939-949
Pat.227811 „Diagnostic set and method for simultaneous detection of mutations within the NF1 gene for the group of patients with suspected Recklinghausen disease” filed on 30.06.2014
PAT.222649 „Method and diagnostic kit for the detection of mutations in the I gene neurofibromin and in patients with suspected neurofibromatosis I type”, fied on 18.12.2012
P-186760 (1997) New binary vector and method of its construction P-186761 (1997) Method of construction of plants resistant to potato virus Y (PVY)
PATENT APPLICATIONS FILLED:
P 369883 „Tropolone analogs as inhibitors of NTPase/helicase of viruses belonging to the Flaviviridae family and as antiviral agents”, filed on 09.03.2004
P 381377 "New acridone derivatives, method of preparation and their application " filed on 12.21.2006
P 381714 „New medical applications of anthracycline antibiotics’ derivatives” filed on 02.07.2007 in the Polish Patent Office, and on 02.07.2008 in the European Patent Office, application No PCT/PL2008/000010
